d4EndgameFarmingGuide

How to Farm Uniques from Bosses in Diablo 4 (Season 8)

Find out which Uniques and Mythic Uniques drop from each Lair Boss.

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Neviriah

WRITER


Updated: April 29th, 2025 at 8:34am


In Diablo 4, players can target farm Uniques, including Mythic Uniques, by defeating specific Lair Bosses. Below, we will cover which bosses drop which Uniques and how to spawn them. You will also find details on cosmetic rewards and links to dedicated guides for each Lair Boss.

Lair Bosses

Lair Bosses are the best way to farm Uniques efficiently. You can fight them from Torment 1 to 4, with higher difficulties offering better chances for Ancestral Uniques. Keep in mind that Duriel, Andariel, and the Harbinger of Hatred have twice the drop rate for Mythic Uniques compared to other Lair Bosses. Belial guarantees an Ancestral Unique drop in his loot, and has the highest Mythic Unique drop chance of all Lair Bosses.

Lair Boss System

Grigoire, The Galvanic Saint

Where: Hall of Penitent in Dry Steppes
Materials: 12xLiving Steel (gathered in Helltides, by opening Tortured Offerings)
Cosmetics: Demonbinder Mount Armor (account bound)

Grigoire Boss Guide
All Classes:
Penitent Greaves

Mythic Uniques:
Melted Heart of Selig
Andariel’s Visage
Harlequin Crest
Ring of Starless Skies
Tyrael’s Might
Heir of Perdition
Shroud of False Death
Shattered Vow
Barbarian:
Twin Strikes
Rage of Harrogath
Battle Trance
The Butcher’s Cleaver
Unbroken Chain
The Grandfather
Doombringer
Druid:
Earthbreaker
Insatiable Fury
Hunter’s Zenith
Waxing Gibbous
The Butcher’s Cleaver
Ahavarion, Spear of Lycander
Doombringer
Necromancer:
Ebonpiercer
Howl from Below
Greaves of the Empty Tomb
The Butcher’s Cleaver
Path of Trag’Oul
The Grandfather
Doombringer
Rogue:
Saboteur’s Signet
Word of Hakan
Grasp of Shadow
Shroud of Khanduras
Doombringer
Sorcerer:
Flameweaver
Staff of Lam Esen
Iceheart Brais
Axial Conduit
Ahavarion, Spear of Lycander
Doombringer
Spiritborn:
Protection of the Prime
Peacemonger’s Signet
Ring of the Midnight Sun
Loyalty’s Mantle
Nesekem, the Herald

Demonbinder Mount Armor:

The Beast in the Ice

Where: Glacial Fissure in Fractured Peaks
Materials: 12x Distilled Fear (gathered in Nightmare Dungeons)
Cosmetics: The Skull Torch and Fell Steed Mount Trophies (account bound)

Beast in the Ice Boss Guide
All Classes:
Fists of Fate
Tassets of the Dawning Sky
Paingorger’s Gauntlets
Mythic Uniques:
Melted Heart of Selig
Andariel’s Visage
Harlequin Crest
Ring of Starless Skies
Tyrael’s Might
Heir of Perdition
Shroud of False Death
Shattered Vow
Barbarian:
Ancients’ Oath
Hellhammer
Ring of the Ravenous
Mantle of Mountain’s Fury
The Grandfather
Doombringer
Druid:
Storm’s Companion
Unsung Ascetic’s Wraps
Stone of Vehemen
Ahavarion, Spear of Lycander
Doombringer
Necromancer:
Ring of Mendeln
Mutilator Plate
The Unmaker
Indira’s Memory
The Grandfather
Doombringer
Rogue:
Windforce
Eaglehorn
Beastfall Boots
Doombringer
Sorcerer:
Gloves of the Illuminator
The Oculus
Starfall Coronet
Strike of Stormhorn
Ahavarion, Spear of Lycander
Doombringer
Spiritborn:
Harmony of Ebewaka
Scorn of the Earth
Wound Drinker
Nesekem, the Herald

The Skull Torch and Fell Steed Mount Trophies:

Varshan

Where: Malignant Burrow in Hawezar (near the Tree of Whispers)
Materials: 12x Malignant Heart (gathered by completing Whispers and as random drop in Helltides)
Cosmetics: Flesh-weld Rod Mount Trophy (account bound)

Varshan Boss Guide
All Classes:
Frostburn
Mother’s Embrace
Mythic Uniques:
Melted Heart of Selig
Andariel’s Visage
Harlequin Crest
Ring of Starless Skies
Tyrael’s Might
Heir of Perdition
Shroud of False Death
Shattered Vow
Barbarian:
Fields of Crimson
100,000 Steps
Gohr’s Devastating Grips
Ring of Red Furor
The Grandfather
Doombringer
Druid:
Mad Wolf’s Glee
Vasily’s Prayer
Greatstaff of the Crone
Airidah’s Inexorable Will
Ahavarion, Spear of Lycander
Doombringer
Necromancer:
Bloodless Scream
Deathless Visage
Deathspeaker’s Pendant
Ring of the Sacrilegious Soul
The Grandfather
Doombringer
Rogue:
Condemnation
Eyes in the Dark
Skyhunter
Writhing Band of Trickery
Doombringer
Sorcerer:
Staff of Endless Rage
Esu’s Heirloom
Raiment of the Infinite
Tal Rasha’s Iridescent Loop
Ahavarion, Spear of Lycander
Doombringer
Spiritborn:
Craze of the Dead God
Ring of the Midday Hunt
Ring of Writhing Moon
Sunstained War-Crozier
Nesekem, the Herald

Flesh-weld Rod Mount Trophy:

Lord Zir

Where: The Darkened Way in Fractured Peaks
Materials: 12x Exquisite Blood (gathered by completing Legion Events or killing World Bosses)
Cosmetics: The Diadem of the Ancient Helm (account bound)

Lord Zir Boss Guide
All Classes:
Razorplate
Temerity
Yen’s Blessing
Mythic Uniques:
Melted Heart of Selig
Andariel’s Visage
Harlequin Crest
Ring of Starless Skies
Tyrael’s Might
Heir of Perdition
Shroud of False Death
Shattered Vow
Barbarian:
Arreat’s Bearing
Ramaladni’s Magnum Opus
Overkill
Ugly Bastard Helm
The Grandfather
Doombringer
Druid:
Wildheart Hunger
Fleshrender
Mjölnic Ryng
Malefic Crescent
Ahavarion, Spear of Lycander
Doombringer
Necromancer:
Cruor’s Embrace
Blood Artisan’s Cuirass
Lidless Wall
Kessime’s Legacy
The Grandfather
Doombringer
Rogue:
Scoundrel’s Kiss
Asheara’s Khanjar
Pitfighter’s Gull
Assassin’s Stride
Doombringer
Sorcerer:
Fractured Winterglass
Esadora’s Overflowing Cameo
Sidhe Bindings
Okun’s Catalyst
Ahavarion, Spear of Lycander
Doombringer
Spiritborn:
Wushe Nak Pa
Band of First Breath
Jacinth Shell
Nesekem, the Herald

The Diadem of the Ancient Helm:

Urivar

Requirement: Vessel of Hatred Expansion
Where: Fields of Judgement in Nahantu
Materials: 12x Judicator’s Mask (gathered by completing Whispers and as random drop in Helltides or killing World Bosses)

Harbinger of Hatred Boss Guide

Greater and Exalted Lair Bosses: Duriel, Andariel, Harbinger of Hatred, and Belial

Duriel:

Where: Gaping Crevasse in Kehjistan
Materials: 3x Shard of Agony (drops from Varshan or Grigoire)
Cosmetics: Smouldering Brimstone Mount (account bound)

Duriel Boss Guide

Andariel:

Where: Hanged Man’s Hall in Kehjistan
Materials: 3x Pincushioned Doll (drops from Lord Zir or The Beast in the Ice)
Cosmetics: Smouldering Brimstone Mount (account bound)

Andariel Boss Guide

Harbinger of Hatred:

Requirement: Vessel of Hatred Expansion
Where: Harbinger’s Den in Nahantu
Materials: 3x Abhorrent Heart (drops from Urivar)

Harbinger of Hatred Boss Guide

Belial:

Where: Palace of the Deceiver in Kehjistan
Materials: 2x Betrayer’s Husk (drops from Belial’s Ambush)
Belial’s loot is unique as you can decide which boss’ loot pool to target before opening the chest.

Belial Boss Guide

For a more detailed page on how to farm Mythic Uniques, check out our dedicated guide:

How to Farm Mythic Uniques
All Classes:
Azurewrath
Godslayer Crown
Flickerstep
Tibault’s Will
X’Fal’s Corroded Signet
Soulbrand
Banished Lord’s Talisman
Mythic Uniques:
Melted Heart of Selig
Andariel’s Visage
Harlequin Crest
Ring of Starless Skies
Tyrael’s Might
Heir of Perdition
Shroud of False Death
Shattered Vow
Barbarian:
Tuskhelm of Joritz the Mighty
The Grandfather
Doombringer
Druid:
Tempest Roar
Dolmen Stone
Ahavarion, Spear of Lycander
Doombringer
Necromancer:
Black River
Blood Moon Breeches
The Grandfather
Doombringer
Rogue:
Cowl of the Nameless
Scoundrel’s Leathers
Doombringer
Sorcerer:
Flamescar
Blue Rose
Ahavarion, Spear of Lycander
Doombringer
Spiritborn:
Rod of Kepeleke
Sepazontec
Nesekem, the Herald

Smouldering Brimstone Mount:

Infernal Hordes

Infernal Hordes also offer you access to certain Uniques. These Uniques can also be gathered from Whisper caches.

Infernal Hordes Guide
All Classes:
Endurant Faith
Rakanoth’s Wake
Shard of Verathiel
Crown of Lucion
Locran’s Talisman
Barbarian:
The Third Blade
Druid:
The Basilisk
Necromancer:
The Mortacrux
Rogue:
The Umbracrux
Sorcerer:
Vox Omnium

Good luck farming your Uniques! Before taking on Lair Bosses, make sure to check which Uniques are best for your build so you can target the right bosses.

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