In Diablo 4, players can target farm Uniques, including Mythic Uniques, by defeating specific Lair Bosses. Below, we will cover which bosses drop which Uniques and how to spawn them. You will also find details on cosmetic rewards and links to dedicated guides for each Lair Boss.
Lair Bosses
Lair Bosses are the best way to farm Uniques efficiently. You can fight them from Torment 1 to 4, with higher difficulties offering better chances for Ancestral Uniques. Keep in mind that Duriel, Andariel, and the Harbinger of Hatred have twice the drop rate for Mythic Uniques compared to other Lair Bosses. Belial guarantees an Ancestral Unique drop in his loot, and has the highest Mythic Unique drop chance of all Lair Bosses.
Lair Boss SystemGrigoire, The Galvanic Saint
Where: Hall of Penitent in Dry Steppes
Materials: 12xLiving Steel (gathered in Helltides, by opening Tortured Offerings)
Cosmetics: Demonbinder Mount Armor (account bound)
Demonbinder Mount Armor:

The Beast in the Ice
Where: Glacial Fissure in Fractured Peaks
Materials: 12x Distilled Fear (gathered in Nightmare Dungeons)
Cosmetics: The Skull Torch and Fell Steed Mount Trophies (account bound)
The Skull Torch and Fell Steed Mount Trophies:

Varshan
Where: Malignant Burrow in Hawezar (near the Tree of Whispers)
Materials: 12x Malignant Heart (gathered by completing Whispers and as random drop in Helltides)
Cosmetics: Flesh-weld Rod Mount Trophy (account bound)
Flesh-weld Rod Mount Trophy:

Lord Zir
Where: The Darkened Way in Fractured Peaks
Materials: 12x Exquisite Blood (gathered by completing Legion Events or killing World Bosses)
Cosmetics: The Diadem of the Ancient Helm (account bound)
The Diadem of the Ancient Helm:

Urivar
Requirement: Vessel of Hatred Expansion
Where: Fields of Judgement in Nahantu
Materials: 12x Judicator’s Mask (gathered by completing Whispers and as random drop in Helltides or killing World Bosses)
Greater and Exalted Lair Bosses: Duriel, Andariel, Harbinger of Hatred, and Belial
Duriel:
Where: Gaping Crevasse in Kehjistan
Materials: 3x Shard of Agony (drops from Varshan or Grigoire)
Cosmetics: Smouldering Brimstone Mount (account bound)
Andariel:
Where: Hanged Man’s Hall in Kehjistan
Materials: 3x Pincushioned Doll (drops from Lord Zir or The Beast in the Ice)
Cosmetics: Smouldering Brimstone Mount (account bound)
Harbinger of Hatred:
Requirement: Vessel of Hatred Expansion
Where: Harbinger’s Den in Nahantu
Materials: 3x Abhorrent Heart (drops from Urivar)
Belial:
Where: Palace of the Deceiver in Kehjistan
Materials: 2x Betrayer’s Husk (drops from Belial’s Ambush)
Belial’s loot is unique as you can decide which boss’ loot pool to target before opening the chest.
For a more detailed page on how to farm Mythic Uniques, check out our dedicated guide:
How to Farm Mythic UniquesSmouldering Brimstone Mount:

Infernal Hordes
Infernal Hordes also offer you access to certain Uniques. These Uniques can also be gathered from Whisper caches.
Infernal Hordes GuideAll Classes: Endurant Faith Rakanoth’s Wake | Shard of Verathiel Crown of Lucion Locran’s Talisman | |
Barbarian: The Third Blade | Druid: The Basilisk | Necromancer: The Mortacrux |
Rogue: The Umbracrux | Sorcerer: Vox Omnium |
Good luck farming your Uniques! Before taking on Lair Bosses, make sure to check which Uniques are best for your build so you can target the right bosses.