Cetonis

You can use one early on, but once the timer hits 40-35 or so, you want to start saving them up so that you have as many to use under buffs as possible. When in doubt, it's free to wait on them and see where the cooldown is compared to your Wanderer's Minuet cooldown timer, if you are going to cap Heartbreak around the same time (or before) WM comes back, fire one off.

1. Good observation on the 5 second gap. The reason it is recommended to go a little wider in the 50-55 open is because before Iron Jaws, we are only going to use our damage over time skills once each at the start. This means that if we do not use Raging before Windbite, that whole run of 15 damage ticks will not be buffed. Whereas with Iron Jaws, we only leave six or so of them unbuffed. Getting that full run of ticks buffed by Raging Strikes is better than buffing a slightly stronger (due to party buffs and Battle Voice) Heavy Shot later on. 2. The first Bloodletter is used imm