Well keybinds do help alot in my experience instead of mouse clicking on abilities/skills/etc, specially if you have specific rotations or priorities and need to react fast to mechanics at the same time during encounters.
With that said you don't need some shift+ctrl+etc crazy keybind, just get a mmo mouse or some other peripheral to help you on that if you don't feel comfortable with just keyboard keybinding.
On the dps part, after you adapt to keybinds you will definitely see an increase on it.